This paper examines Africa in post-Cold War world politics by looking at political, strategic and economic relations in the world. The findings suggest that Africa had suffered marginalization in the past, and is suffering it in post- Cold War world politics. This is because dominant international actors like powerful nations (the US, Britain, France), international organizations (the UN, Commonwealth etc), International Financial Institutions (the IMF, World Bank etc) do not consider Africa as a priority entity in world affairs, yet Africa is coming under more constraints to follow values and beliefs of these same international actors, which has led African states to greater dependence for policy reforms. The consequences have resulted in increased debt, social hardship, environmental degradation, poverty, unemployment, crime, iknter and intra-state conflicts in post-Cold War Africa. The paper concludes that, in addition to collective action, African states should individually redefine and redirect their national interests with a view to enhancing their national power to play active role in the power equation of world politics.